A Case of Acute Promyelocytic Leukemia with Phenotypic Change at Relapse / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 358-361, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-97658
ABSTRACT
Early diagnosis of acute promyelocytic leukemia (APL) depends primarily on morphological recognition before the presence of t(15;17) or PML-RAR gene rearrangement is confirmed. But the diagnosis is difficult to be made, if typical APL morphologic features are not found. Here, we describe a 32- year old man who had been diagnosed as APL. He relapsed with AML M1 like phenotype, lacking the typical features of APL. At relapse, t(15;17) and PML-RAR alpha gene rearrangement were detected. After 14 days of chemotherapy and all-trans retinoic acid, the phenotype changed from the AML M1 like features to the typical hypergranular APL. Awareness of atypical morphologic subtypes found in APL is important. And identification of t(15;17) or PML/RAR alpha rearrangement will be helpful in diagnosis of atypical APL.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Recidiva
/
Tretinoína
/
Rearranjo Gênico
/
Leucemia Promielocítica Aguda
/
Diagnóstico Precoce
/
Diagnóstico
/
Tratamento Farmacológico
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Coreano
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2004
Tipo de documento:
Artigo
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