Adverse Pregnancy Outcomes Are Associated With Lower Cut-offs for Maternal Hyperglycemia in Malaysian Women: A Retrospective Cohort Study
Malaysian Journal of Medicine and Health Sciences
;
: 55-62, 2021.
Artigo
em Inglês
| WPRIM
| ID: wpr-978936
ABSTRACT
@#Introduction:
This cohort aimed to determine glycemia distribution of pregnant women and maternal glycemia categories and its correlation with adverse pregnancy outcomes among Malaysian women.Methods:
A retrospective cohort study of normal glycemia pregnant women. Binary logistic regression was used to examine the associations between maternal glycemia categories and adverse outcomes.Results:
Women with elevated fasting plasma glucose (FPG) were at lower risk of having SGA infants (aORFPG 4= 0.64, 95% CI= 0.47 – 0.85; aORFPG 6= 0.68, 95% CI= 0.43–0.98; aORFPG 7= 0.64, 95% CI= 0.42–0.96) than those women in category 1. Women in the higher 2-hour plasma glucose (2hPG) category had a nearly two-fold risk of having LBW and LGA infants. Hyperglycemia less severe than gestational diabetes mellitus (GDM) was associated with LGA (aOR= 1.22, 95% CI= 1.07 – 1.88) and caesarean delivery (aOR= 1.80, 95% CI= 1.20 – 2.69), in the meanwhile GDM was associated with caesarean delivery (aOR= 1.33, 95% CI= 1.02 –1.79).Conclusion:
Cut-off points for FPG and 2hPG that relate to adverse pregnancy outcomes started at 4.9 – 5.0 mmol/l and 7.5 – 7.7 mmol/l. These cut-off points were lower than the current recommended criteria of Clinical Practice Guideline (CPG) of Malaysia for GDM diagnosis. Large-scale studies are required to identify the optimal GDM cut-off.
Buscar no Google
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Malaysian Journal of Medicine and Health Sciences
Ano de publicação:
2021
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS