Roles of Long Noncoding RNAs and Glycolysis in Digestive System Tumors / 中山大学学报(医学科学版)

ABSTRACT

Long noncoding RNAs （LncRNAs）， a class of noncoding RNAs greater than 200 bases in length， are widely involved in the initiation， progression and glycolytic processes of many tumors， and can act as competitive endogenous RNA sponges to absorb miRNAs. LncRNAs can also inhibit miRNA expression， thereby regulate the glycolysis of tumor cells， affects cell proliferation， invasion and other biological activities. This review explores the roles of LncRNAs and glycolysis in digestive system tumors （DST）， a representative group of malignant tumors. Extending the LncRNA role in the diagnosis， treatment and prognosis of other tumors， we conclude that LncRNAs have the potential to be new candidate genes for tumorigenesis and serve as tumor biomarkers， which provides new insight into morbidity and mortality decrease of DST and other tumors.