Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases / 中国修复重建外科杂志
Chinese Journal of Reparative and Reconstructive Surgery
;
(12): 758-763, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-981665
ABSTRACT
OBJECTIVE@#To review the research progress of mitochondrial dynamics mediated by optic atrophy 1 (OPA1) in skeletal system diseases.@*METHODS@#The literatures about OPA1-mediated mitochondrial dynamics in recent years were reviewed, and the bioactive ingredients and drugs for the treatment of skeletal system diseases were summarized, which provided a new idea for the treatment of osteoarthritis.@*RESULTS@#OPA1 is a key factor involved in mitochondrial dynamics and energetics and in maintaining the stability of the mitochondrial genome. Accumulating evidence indicates that OPA1-mediated mitochondrial dynamics plays an important role in the regulation of skeletal system diseases such as osteoarthritis, osteoporosis, and osteosarcoma.@*CONCLUSION@#OPA1-mediated mitochondrial dynamics provides an important theoretical basis for the prevention and treatment of skeletal system diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoartrite
/
Osteoporose
/
Dinâmica Mitocondrial
/
GTP Fosfo-Hidrolases
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Reparative and Reconstructive Surgery
Ano de publicação:
2023
Tipo de documento:
Artigo
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