Research Progress of Next Generation Sequencing in Acute Leukemia --Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 612-615, 2023.
Article
em Zh
| WPRIM
| ID: wpr-982105
Biblioteca responsável:
WPRO
ABSTRACT
With the advent of precision medicine, next-generation sequencing (NGS) is playing an increasingly important role in clinical oncology diagnosis and treatment with its advantages of high sensitivity, high accuracy, high efficiency and operability. NGS reveals the genetic characteristics of acute leukemia(AL) patients by screening for specific disease-causing genes to identify occult as well as complex genetic mutations in patients with AL, leading to early diagnosis and targeted drug therapy for AL patients, as well as to predict disease recurrence by detecting mnimal residual disease (MRD) and analyzing mutated genes to determine patient prognosis. NGS plays an increasingly important role in the diagnosis, treatment and prognosis assessment in AL, providing a direction for the pursuit of precision medicine. This paper reviews the research progress of NGS in AL.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Recidiva
/
Leucemia Mieloide Aguda
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Doença Aguda
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Neoplasia Residual
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Sequenciamento de Nucleotídeos em Larga Escala
/
Mutação
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2023
Tipo de documento:
Article