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LIMP-2 enhances cancer stem-like cell properties by promoting autophagy-induced GSK3β degradation in head and neck squamous cell carcinoma / 国际口腔科学杂志·英文版
International Journal of Oral Science ; (4): 24-24, 2023.
Artigo em Inglês | WPRIM | ID: wpr-982481
ABSTRACT
Cancer stem cell-like cells (CSCs) play an integral role in the heterogeneity, metastasis, and treatment resistance of head and neck squamous cell carcinoma (HNSCC) due to their high tumor initiation capacity and plasticity. Here, we identified a candidate gene named LIMP-2 as a novel therapeutic target regulating HNSCC progression and CSC properties. The high expression of LIMP-2 in HNSCC patients suggested a poor prognosis and potential immunotherapy resistance. Functionally, LIMP-2 can facilitate autolysosome formation to promote autophagic flux. LIMP-2 knockdown inhibits autophagic flux and reduces the tumorigenic ability of HNSCC. Further mechanistic studies suggest that enhanced autophagy helps HNSCC maintain stemness and promotes degradation of GSK3β, which in turn facilitates nuclear translocation of β-catenin and transcription of downstream target genes. In conclusion, this study reveals LIMP-2 as a novel prospective therapeutic target for HNSCC and provides evidence for a link between autophagy, CSC, and immunotherapy resistance.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Autofagia / Células-Tronco Neoplásicas / Carcinoma de Células Escamosas / Linhagem Celular Tumoral / Proteínas de Membrana Lisossomal / Glicogênio Sintase Quinase 3 beta / Carcinoma de Células Escamosas de Cabeça e Pescoço / Neoplasias de Cabeça e Pescoço Limite: Humanos Idioma: Inglês Revista: International Journal of Oral Science Ano de publicação: 2023 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Autofagia / Células-Tronco Neoplásicas / Carcinoma de Células Escamosas / Linhagem Celular Tumoral / Proteínas de Membrana Lisossomal / Glicogênio Sintase Quinase 3 beta / Carcinoma de Células Escamosas de Cabeça e Pescoço / Neoplasias de Cabeça e Pescoço Limite: Humanos Idioma: Inglês Revista: International Journal of Oral Science Ano de publicação: 2023 Tipo de documento: Artigo