Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder
Psychiatry Investigation
;
: 349-355, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-98263
ABSTRACT
OBJECTIVE:
To investigate the impact of regular cannabis use on long-term remission of mood symptoms in bipolar spectrum disorders.METHODS:
The 24-month prospective observational study included patients (n=239) with bipolar I disorder and schizoaffective disorder, bipolar type. Participants were classified as regular cannabis users (three times or more per week) or non-users. The primary outcome measure was the achievement of remission on the evaluations during the 24 months.RESULTS:
Of the 234 participants for whom data was available, 25 (10.7%) were regular cannabis users, and the group comprised significantly more males than females. In the total population, cannabis use was significantly associated with decreased likelihood of remission during the 24-month follow-up period. Subgroup analyses showed that cannabis use was significantly associated with lower remission rates on the Hamilton Depression Rating Scale in females (n=139) and patients prescribed mood stabilizers alone (n=151), whereas in males (n=95) and patients prescribed olanzapine and/or a mood stabilizer (n=83), cannabis use was significantly associated with lower remission rates on the Young Mania Rating Scale. Remission rates were lowest in the concurrent cannabis and tobacco smoking group (n=22) followed by the tobacco smoking only group (n=97), and the non-smoker group (n=116). The post-hoc analysis revealed that all remission rates were significantly lower in the concurrent cannabis and the tobacco smoking group compared to the non-smoker group.CONCLUSION:
Cannabis use negatively affects the long-term clinical outcome in patients with bipolar spectrum disorders. A comprehensive assessment and integrated management of cannabis use are required to achieve better treatment outcomes for bipolar spectrum disorders.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtornos Psicóticos
/
Transtorno Bipolar
/
Cannabis
/
Fumar
/
Estudos Prospectivos
/
Seguimentos
/
Avaliação de Resultados em Cuidados de Saúde
/
Depressão
/
Estudo Observacional
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Psychiatry Investigation
Ano de publicação:
2015
Tipo de documento:
Artigo
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