Potential implications of ketone body metabolism changes and ketogenic therapy in the treatment of heart failure / 中华危重病急救医学
Chinese Critical Care Medicine
;
(12): 769-772, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-982672
ABSTRACT
Heart failure (HF) has become a major challenge in the treatment of global cardiovascular diseases. Great progress has been made in the drug treatment of HF, however, rehospitalization rate and mortality of patients with HF are still high. Hence, there is an urgent need to explore new treatment strategy and new underlying pathogenic mechanisms. In recent years, some researchers have suggested that regulation of ketone body metabolism may become a potentially promising therapeutic approach for HF. Some studies showed that the oxidative utilization of fatty acids and glucose was decreased in the failing heart, accompanied by the increase of ketone body oxidative metabolism. The enhancement of ketone body metabolism in HF is a compensatory change during HF. The failing heart preferentially uses ketone body oxidation to provide energy, which helps to improve the body's cardiac function. This review will discuss the potential significance of ketone body metabolism in the treatment of HF from three aspects normal myocardial ketone body metabolism, the change of ketone body metabolism in HF, the effect of ketogenic therapy on HF and its treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Cardiovasculares
/
Metabolismo Energético
/
Ácidos Graxos
/
Insuficiência Cardíaca
/
Corpos Cetônicos
/
Miocárdio
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Critical Care Medicine
Ano de publicação:
2023
Tipo de documento:
Artigo
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