Cell apoptosis in closed cerebellar contusion in rat / 法医学杂志

ABSTRACT

OBJECTIVE@#To observe the cell apoptosis explore closed cerebellar contusion in rat.@*METHODS@#SD rats model of contusion was established and apototic cells were detected by TUNEL method at 5, 10, 30, 45, 60 min and 2, 4, 6, 8, 12 h, after injury.@*RESULTS@#Apototic cells in contusion area appeared at 1 h after closed cerebellar contusion, reached the peak at 4-6 h, then decreased and so as marginal area where the peak was in 6-8 h.@*CONCLUSION@#The apoptotic index of closed contusion of cerebellum in different injury time may provide a new sensitive and objective method for the forensic early injury time estimation.