Experimental pathological study of subacute intoxication by Dioscorea bulbifera L / 法医学杂志
Journal of Forensic Medicine
;
(6): 81-83, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-982976
ABSTRACT
OBJECTIVE@#To study the pathological change and the toxic mechanism of Dioscorea bulbifera L in mice.@*METHODS@#Sixty ICR mice were randomly assigned to four groups poisoned respectively with 200% Dioscorea bulbifera L of 1/4 LD50, 1/10LD50, 1/30LD50 and a control group treated with distilled water by oral administration. All animals were pathologically examined with LM and some of them were examined with TEM when the mice died during the experiment or the survival mice were sacrificed after thirty days.@*RESULTS@#The pathological changes showed fatty change and the increasing glycogen of liver cells; degeneration and necrosis of the epithelia of uriniferous tubules. The serum BUN and ALT of the experimental groups mice were higher than that of control group. Enzyme histochemical staining showed the decreasing activity of G-6-P and SDH in the liver cells in the experimental groups.@*CONCLUSION@#The experiment suggests that the target organs were liver and kidney. The toxic mechanism of Dioscorea bublifera L was the damage of the mitochondrional and endoplasmic reticulum membrane directly. As a result, the activity of the SDH and G-6-P decreased, the metabolism was affected.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Mitocôndrias Hepáticas
/
Distribuição Aleatória
/
Dioscorea
/
Retículo Endoplasmático
/
Doença Hepática Induzida por Substâncias e Drogas
/
Medicina Legal
/
Rim
/
Camundongos Endogâmicos ICR
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2003
Tipo de documento:
Artigo
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