Mitochondrial apoptotic signaling pathway in neurons following brain injury induced by hypoxia / 法医学杂志
Journal of Forensic Medicine
;
(6): 178-182, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-983042
ABSTRACT
Impairment of neuronal mitochondria following hypoxia of brain not only result in nerve cell's energy-deprivation and dysfunction, mitochondria also play key roles in apoptosis of neurons. A central step being the release of cytochrome c (cyt c) across the outer mitochondrial membrane into the cytoplasm through opening of the mitochondrial permeability transition pore. Releasing of cytochrome c induce to downstream consequences of specific caspase activation. The antiapoptotic and proapoptotic members of the Bcl-2 family regulate mitochondrial activities relevant to apoptotic signaling by influencing the realaseing of cyt c.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transdução de Sinais
/
Hipóxia Encefálica
/
Apoptose
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Caspases
/
Grupo dos Citocromos c
/
Proteínas de Membrana
/
Mitocôndrias
/
Neurônios
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2004
Tipo de documento:
Artigo
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