The study on HLA-Cw polymorphism from Xi'an Han population by PCR-sequence specific oligonucleotide probe / 法医学杂志

ABSTRACT

OBJECTIVE@#To determine the HLA-Cw allele and genotype frequencies from Xi'an Han population and obtain genetic data.@*METHODS@#The results of HLA-Cw typing for 130 randomly selected from Xi'an Han population were obtained by using the PCR-Sequence Specific Oligonucleotide Probes (SSOP).@*RESULTS@#In this investigation, 16 alleles were detected among 130 unrelated individuals with frequencies from 0.0077 to 0.1588 and HLA-Cw*01,03,07 were the most common HLA-Cw alleles. We have made a survey of HLA-Cw alleles frequencies in Xi'an Han Population, with blank frequency being lowered to 0.018 2.@*CONCLUSION@#The distribution of genotype frequencies met the law of Hardy-Weinberg equilibrium by Hi-square test. The frequency data can be used in forensic and paternity tests, transplant matching and anthropology.