Study on identification of aconiti by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry / 法医学杂志
Journal of Forensic Medicine
;
(6): 118-120, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-983087
ABSTRACT
OBJECTIVE@#The merhod of determination of traditional Chinese medicine of aconitum root has been established by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.@*METHODS@#With optimized matrix of 2,5-Dihydroxy- benzoic acid for herbal extract, the identification of aconitum root by MALDI-TOF-MS has been conditioned. By comparison of mass spetra of various of aconitium root, their fingerprint mass-to-charge ratios were found to perform identification. With the characteristic mass-to-charge ratios, It was shown that the mass spectrum of raw aconitum roots were obviously different from that of processed aconitum roots.@*RESULTS@#The raw radix aconiti could be differentiated from radix aconiti preparate by determination of MALDI-TOF-MS.@*CONCLUSION@#The identifical method of aconitum root by MALDI-TOF-MS is rapid, precise and sensitive, it can be used in toxicological analysis of medical tangle and illegal medical practice.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas Medicinais
/
Controle de Qualidade
/
Aconitina
/
Medicamentos de Ervas Chinesas
/
Sensibilidade e Especificidade
/
Tecnologia Farmacêutica
/
Raízes de Plantas
/
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
/
Aconitum
/
Etanol
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo
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