Changes of cyclin D1 expression following human brain contusion / 法医学杂志
Journal of Forensic Medicine
;
(6): 245-250, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-983189
ABSTRACT
OBJECTIVE@#To study the relationships of Cyclin D1 expression with the posttraumatic intervals (PTI) following the cerebra, brainstem or cerebella contusion in human.@*METHODS@#88 cases of brain contusions of the closed head injury were investigated with pathological and Cyclin D1 immunohistochemistry methods. The results were analyzed by image analysis technique (IAT).@*RESULTS@#The immunoreactivity of Cyclin D1 was almost disappeared in the core cells of the brain contusion. Cyclin D1-positive cells started to increase in the boundary of the brain contusion in the 1h group. Cyclin D1-positive cells were increased significantly in the 3 h-30 d groups and maintained at a high level in the boundary of the brain contusion of those groups. It is suggested that the Cyclin D1-positive cells were primarily origin from microglia and other glia. A few neurons expressed Cyclin D1.@*CONCLUSION@#Cyclin D1 can express in several kinds of brain cells following the contusion, especially in the glia cells. Cyclin D1-positive cells were increased obviously and rapidly after injury, so it could be used as a reference marker for early stage brain injury.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Coloração e Rotulagem
/
Fatores de Tempo
/
Encéfalo
/
Lesões Encefálicas
/
Imuno-Histoquímica
/
Neuroglia
/
Astrócitos
/
Ciclina D1
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2006
Tipo de documento:
Artigo
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