Development of a gas chromatography-mass spectrometry method for the quantification of propofol in blood / 法医学杂志
Journal of Forensic Medicine
; (6): 313-314, 2006.
Article
em Zh
| WPRIM
| ID: wpr-983211
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#A rapid and selective method has been developed for the determination of propofol in blood by gas chromatography-mass spectrometry (GC-MS).@*METHODS@#The blood was extrasted with the solution of internal standard, the extracted residue was analyzed by gas chromatography-mass spectrometry using selected-ion monitoring mode.@*RESULTS@#The linear range was 0.1-10 microg/mL. The coefficient(R2) was 0.993 1. The detection limit was 0.05 microg/mL.@*CONCLUSION@#The method is simple and rapid, offering superior sensitivity and selectivity for propofol. The method can be used successfully during clinical and forensic toxicology.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Propofol
/
Reprodutibilidade dos Testes
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Sensibilidade e Especificidade
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Anestésicos Intravenosos
/
Cromatografia Gasosa-Espectrometria de Massas
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Ano de publicação:
2006
Tipo de documento:
Article