Dynamic observation of brainstem auditory evoked potential and pathological changes of the brain after closed brain injuries in rats / 法医学杂志
Journal of Forensic Medicine
;
(6): 324-327, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-983213
ABSTRACT
OBJECTIVE@#To investigate the dynamic experiences of pathological changes in brain and the injured role of brainstem auditory evoked potential (BAEP) after closed Mild Traumatic Brain Injury (MTBI) in rat.@*METHODS@#A closed diffuse brain injury model was successfully produced in rat by hit the parietal bone with a spring-droved steel stick. The auditory brainstem response evoked by click at 50Hz stimulating frequency were recorded at pre-trauma, 15 min and 1, 3, 6, 12 h and 1, 2, 4, 7, 10, 14, 21 d after brain injury. The pathological changes of brain were observed under light microscope and the brain edema was detected by wet weight/dry weight rations.@*RESULTS@#The I-V, III-V of BAEP wave inter peak latency (IPL) in MTBI group increased immediately in 15 minutes after injury. The III, V wave peak latency (PL) and I-V, III-V wave IPL became longer than the pre-trauma level in 6, 12 h post-injury (P<0.05). The III, V wave PL and I - III, I - V, III - V wave IPL became longer than the pre-trauma level in 1, 2 d after injury (P < 0.001), the BAEP retuned to normal level in 14 d after brain injury. At 15 minutes after injury, the water content in brain increased and met its peak in 1 d, decreased gradually in 4 d, then decreased slowly and returned to normal level in 10 d after injury.@*CONCLUSION@#The regular changes of BAEP could be an objective tool for evaluating hearing dysfunction after closed mild diffuse traumatic brain injury.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtornos da Percepção Auditiva
/
Encéfalo
/
Edema Encefálico
/
Lesões Encefálicas
/
Tronco Encefálico
/
Distribuição Aleatória
/
Potenciais Evocados Auditivos do Tronco Encefálico
/
Ratos Sprague-Dawley
/
Modelos Animais de Doenças
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2006
Tipo de documento:
Artigo
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