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A color test for rapid screening of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in drink and urine / 法医学杂志
Journal of Forensic Medicine ; (6): 424-427, 2006.
Artigo em Chinês | WPRIM | ID: wpr-983239
ABSTRACT
OBJECTIVE@#A rapid color test for screening gamma-hydroxybutyric acid (GHB) and its precursor gamma-butyrolactone(GBL) was investigated in drink and urine samples.@*METHODS@#In an acidic solution, GHB was converted to GBL, which reacted with hydroxylamine hydrochloride in presence of sodium hydroxide, forming hydroxamate. A purple complex was formed when hydroxamate reacted with ferric chloride in acidic condition.@*RESULTS@#Detection limit concentrations of GHB in drinks were between 0.5-2 mg/mL, less than the popular abuse concentrations of GHB. This method was usable for urine, with detection limit concentration 0.5 mg/mL. Interferences of common organic solvents and narcotics and depressants were surveyed.@*CONCLUSION@#This method is simple, safe, and rapid; it facilitates rapid screening of GHB and GBL in clinic and forensic laboratories.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Solventes / Ácidos Sulfúricos / Bebidas / 4-Butirolactona / Bebidas Alcoólicas / Medicina Legal / Concentração de Íons de Hidrogênio / Hidroxibutiratos / Anestésicos Limite: Humanos Idioma: Chinês Revista: Journal of Forensic Medicine Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Solventes / Ácidos Sulfúricos / Bebidas / 4-Butirolactona / Bebidas Alcoólicas / Medicina Legal / Concentração de Íons de Hidrogênio / Hidroxibutiratos / Anestésicos Limite: Humanos Idioma: Chinês Revista: Journal of Forensic Medicine Ano de publicação: 2006 Tipo de documento: Artigo