Detection of gamma-hydroxybutyrate (GHB) in beverages / 法医学杂志
Journal of Forensic Medicine
; (6): 120-129, 2007.
Article
em Zh
| WPRIM
| ID: wpr-983280
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To establish an analytical method for the determination of GHB in beverages using GC/MS and LC/MS/MS.@*METHODS@#After beverage samples with GHB-d6 as the internal standard were extracted with ethyl acetate, then the extracts were derivatized with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), at last the derivateized extracts analyzed by gas chromatography- mass spectrometry. After beverage samples with GHB-d6 as the internal standard were diluted by mobile phase then directly analyzed by LC/MS/MS. Results The limit of detection was 0.2 microg/mL and both relative standard deviations for between-day and within-day assays were < 8.54% in GC/MS. The limit of detection was 2 microg/mL and both relative standard deviations for between-day and within-day assays were <8.62% in LC/MS/MS. Conclusion These methods of qualitative and quantitative analysis were found to be sensitive, accurate, rapid and suitable for the forensic toxicology to test of GHB in real cases.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Oxibato de Sódio
/
Bebidas
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Detecção do Abuso de Substâncias
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Reprodutibilidade dos Testes
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Sensibilidade e Especificidade
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Anestésicos Intravenosos
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Medicina Legal
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Concentração de Íons de Hidrogênio
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Cromatografia Gasosa-Espectrometria de Massas
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Ano de publicação:
2007
Tipo de documento:
Article