The effects of heroin on intracellular free Ca2+ of rat myocardium / 法医学杂志
Journal of Forensic Medicine
;
(6): 424-427, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-983331
ABSTRACT
OBJECTIVE@#To observe the effects of heroin on intracellular free Ca2+ in rat myocardium.@*METHODS@#The effects of heroin on intracellular free Ca2+ were observed in cultured neonatal rat myocardium by measuring intracellular free Ca2+ concentration using calcium fluorescent probe Flou-3/AM and laser scanning confocal microscope.@*RESULTS@#Different doses and concentrations of heroin appeared to have different effects on intracellular free Ca2+ concentrations, with a dosage dependent short linear increase in the fluorescence intensity (i.e., Ca2+ concentration) leading to [Ca2+]i peak.@*CONCLUSION@#Heroin could affect concentrations of [Ca2+]i in myocardium and its dosage related effect needs further investigation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células Cultivadas
/
Cálcio
/
Ratos Sprague-Dawley
/
Microscopia Confocal
/
Sinalização do Cálcio
/
Miócitos Cardíacos
/
Heroína
/
Relação Dose-Resposta a Droga
/
Microscopia de Fluorescência
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2007
Tipo de documento:
Artigo
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