The role of dopamine D3 receptor in the amphetamine-induced conditioned place preference in mice / 法医学杂志
Journal of Forensic Medicine
;
(6): 428-430, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-983332
ABSTRACT
OBJECTIVE@#To study the role of dopamine D3 receptor involved in the amphetamine-induced conditioned place preference (CPP) in mice.@*METHODS@#The CPP was observed in D3 receptor knock-out (D3RKO) mice and C57BL/6 wild-type control mice after administration of amphetamine. The data were analyzed with a two-way ANOVA using the SPSS 13.0 software.@*RESULTS@#D3RKO mice showed a significant amphetamine-induced CPP (P<0.001), compared with the ones administered with saline in C57BL/6 control mice.@*CONCLUSION@#The results indicate that amphetamine can produce significant CPP in dopamine D3 receptor knock-out mice, suggesting that amphetamine-induced addiction can be inhibited by dopamine D3 receptor.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tempo de Reação
/
Comportamento Animal
/
Camundongos Knockout
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Condicionamento Operante
/
Modelos Animais de Doenças
/
Receptores de Dopamina D3
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Técnicas de Inativação de Genes
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Anfetamina
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Camundongos Endogâmicos C57BL
/
Atividade Motora
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2007
Tipo de documento:
Artigo
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