Effect of temperature and time on stability of ketamine in biological samples / 法医学杂志
Journal of Forensic Medicine
;
(6): 434-436, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-983520
ABSTRACT
OBJECTIVE@#The stability of ketamine in biological samples was studied under different storage temperature and time.@*METHODS@#The rabbits were given intragastric administration of ketamine with a dose of 150 mg/kg and were sacrificed after 30 minutes. Blood, liver, kidney and brain of the rabbits were stored at room temperature (between 18 degrees C and 24 degrees C) and -20 degrees C. The specimens were analyzed at different times by GC-MS and GC-NPD.@*RESULTS@#At -20 degrees C, the concentration of ketamine decreased in all of samples (P < 0.05) within 30 days. The concentration of ketamine increased in all of samples stored at room temperature after 5 days(P < 0.05).@*CONCLUSION@#The stability of ketamine in biological samples stored at -20 degrees C was better than that at room temperature. The samples suspected containing ketamine should be stored at -20 degrees C and should be tested as soon as possible.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Manejo de Espécimes
/
Temperatura
/
Fatores de Tempo
/
Encéfalo
/
Criopreservação
/
Modelos Animais de Doenças
/
Estabilidade de Medicamentos
/
Toxicologia Forense
/
Concentração de Íons de Hidrogênio
/
Ketamina
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2009
Tipo de documento:
Artigo
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