Immunohistochemical expression of HO-1 in traumatic human brain tissue / 法医学杂志
Journal of Forensic Medicine
;
(6): 325-331, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-983587
ABSTRACT
OBJECTIVE@#To investigate the expression of heme oxygenase-1 (HO-1) at different intervals and to provide evidence for estimation on injury intervals after brain contusion in human.@*METHODS@#Twenty-four patients died of serious brain injury were assigned as injury group and 4 patients died of non-brain injury were served as control group. HO-1 expression was analyzed in brain tissue at different time intervals (3 h, 6-9 h, 12-24 h, 36 h-3d, 5-8d, 17-20d) by immunohistochemistry and auto-image analysis system.@*RESULTS@#The level of HO-1 expression started to increase in 3 h after brain contusion compared to the control group (P < 0.05). The level of HO-1 expression highest level in 12-24 h group, and maintained high level in 36 h-3 d, then decreased gradually.@*CONCLUSION@#The expression of HO-1 might be a strong evidence for human brain contusion time estimation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Autopsia
/
Coloração e Rotulagem
/
Fatores de Tempo
/
Encéfalo
/
Lesões Encefálicas
/
Imuno-Histoquímica
/
Estudos de Casos e Controles
/
Patologia Legal
/
Heme Oxigenase-1
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2010
Tipo de documento:
Artigo
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