Expression of CAR in myocardial of viral myocarditis and dilated cardiomyopathy / 法医学杂志
Journal of Forensic Medicine
;
(6): 328-331, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-983588
ABSTRACT
OBJECTIVE@#In order to improve accuracy and reliability of forensic diagnosis of sudden cardiac death, pathogenesis and relationship between the viral myocarditis (VMC) and dilated cardiomyopathy (DCM) were investigated.@*METHODS@#Improved immunohistochemical technique was used to detect the expression of the CAR in myocardium samples, including 22 deceased with VMC, 20 deceased with DCM and 16 control deceased.@*RESULTS@#The brown staining on the cell membrane of myocardium showed positive result. There was a prominent CAR expression in VMC group and DCM group, which were statistically significant difference compared with control group (P < 0.05).@*CONCLUSION@#The CAR expression showed significantly higher in VMC and DCM groups. The viral infection can result in myocardial necrosis and impaired cardiac functions. These abnormalities can trigger a cascade of events that contributed to the progress of VMC to DCM.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Receptores Virais
/
Coloração e Rotulagem
/
Imuno-Histoquímica
/
Cardiomiopatia Dilatada
/
Estudos de Casos e Controles
/
Morte Súbita Cardíaca
/
Infecções por Coxsackievirus
/
Patologia Legal
/
Proteína de Membrana Semelhante a Receptor de Coxsackie e Adenovirus
/
Miocardite
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2010
Tipo de documento:
Artigo
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