Stability of estazolam in dog tissues preserved in formaldehyde solution / 法医学杂志
Journal of Forensic Medicine
;
(6): 117-124, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-983636
ABSTRACT
OBJECTIVE@#To investigate the stability of estazolam in biological samples preserved in formaldehyde solution.@*METHODS@#The dog was given intragastric administration of estazolam with a dose of 37.6 mg/kg and killed 2 h later. Heart, liver, kidney and brain of the dog were cut up into 1 g and preserved in 4% formaldehyde solution respectively. The content of estazolam in biological samples and formaldehyde solution were analyzed by HPLC at different times.@*RESULTS@#The content of estazolam in heart, liver, kidney and brain or in formaldehyde solution reduced gradually followed with the extention of preservation time. At the 63rd day, estazolam content in four tissues were 0.8%, 1.7%, 1.0% and 2.2% of the original content respectively.@*CONCLUSION@#Estazolam in tissues can diffuse into formaldehyde solution and decomposed quickly, so biological samples contained estazolam should not be preserved in formaldehyde solution.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Soluções
/
Fatores de Tempo
/
Preservação de Tecido
/
Química Encefálica
/
Administração Oral
/
Cromatografia Líquida de Alta Pressão
/
Estabilidade de Medicamentos
/
Estazolam
/
Toxicologia Forense
/
Formaldeído
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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