Time-dependent recruitment and differentiation of fibrocytes in mouse skin wound healing / 法医学杂志
Journal of Forensic Medicine
;
(6): 246-249, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-983657
ABSTRACT
OBJECTIVE@#To investigate the time-dependent recruitment and differentiation of fibrocytes in skin wound healing.@*METHODS@#Fibrocytes (expressing CD45 and procollagen I ) and myofibroblasts (expressing CD45 and alpha-SMA) were co-localized by immunofluorescent staining. The number of fibrocytes and myofibroblasts was counted at different post-wounding interval.@*RESULTS@#At 3 d after injury, fibrocytes started to recruit at the margin of the wounds. At 5 d after injury, myofibroblasts started to appear in new formed granulation tissue. The number of fibrocytes and myofibroblasts peaked at 7 d post-wounding.@*CONCLUSION@#During skin wound healing, myofibroblasts in granulation tissue originated at least partly from fibrocytic differentiation. The time-dependent recruitment and differentiation of fibrocytes may provide new information for wound age determination.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Coloração e Rotulagem
/
Fatores de Tempo
/
Cicatrização
/
Contagem de Células
/
Diferenciação Celular
/
Antígenos Comuns de Leucócito
/
Modelos Animais de Doenças
/
Miofibroblastos
/
Fibroblastos
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS