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The expression of GABA(A) receptor alpha1 and GABA(B) receptor 1 in medulla oblongata solitary nucleus and ambiguous nucleus in the cases of tramadol intoxication / 法医学杂志
Journal of Forensic Medicine ; (6): 401-404, 2011.
Article em Zh | WPRIM | ID: wpr-983687
Biblioteca responsável: WPRO
ABSTRACT
OBJECTIVE@#To observe the expression of GABA(A) receptor alpha1 (GABA(A)alpha1) and GABA(B) receptor 1 (GABA(B)1) in human medulla oblongata solitary nucleus and ambiguous nucleus due to tramadol-induced death.@*METHODS@#GABA(A)alpha1 and GABA(B)1 were detected by immunohistochemical SP method in tramadol-induced death group and control group. All results were evaluated by images analysis system.@*RESULTS@#Low expression of GABA(A)alpha1 and GABA(B)1 were detected in solitary nucleus and ambiguous nucleus in the control brain tissue. In cases of tramadol-induced death, the expression of GABA(A)alpha1 and GABA(B)1 significantly increased.@*CONCLUSION@#The mechanism of tramadol intoxication death could be caused by respiratory depression induced by over-expression of GABA(A)alpha1 and GABA(B)1 in medulla oblongata solitary nucleus and ambiguous nucleus.
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Transtornos Respiratórios / Autopsia / Coloração e Rotulagem / Tramadol / Bulbo / Imuno-Histoquímica / Estudos de Casos e Controles / Causas de Morte / Núcleo Solitário / Receptores de GABA-B Limite: Adult / Female / Humans / Male Idioma: Zh Revista: Journal of Forensic Medicine Ano de publicação: 2011 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Transtornos Respiratórios / Autopsia / Coloração e Rotulagem / Tramadol / Bulbo / Imuno-Histoquímica / Estudos de Casos e Controles / Causas de Morte / Núcleo Solitário / Receptores de GABA-B Limite: Adult / Female / Humans / Male Idioma: Zh Revista: Journal of Forensic Medicine Ano de publicação: 2011 Tipo de documento: Article