The expression of GABA(A) receptor alpha1 and GABA(B) receptor 1 in medulla oblongata solitary nucleus and ambiguous nucleus in the cases of tramadol intoxication / 法医学杂志
Journal of Forensic Medicine
; (6): 401-404, 2011.
Article
em Zh
| WPRIM
| ID: wpr-983687
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To observe the expression of GABA(A) receptor alpha1 (GABA(A)alpha1) and GABA(B) receptor 1 (GABA(B)1) in human medulla oblongata solitary nucleus and ambiguous nucleus due to tramadol-induced death.@*METHODS@#GABA(A)alpha1 and GABA(B)1 were detected by immunohistochemical SP method in tramadol-induced death group and control group. All results were evaluated by images analysis system.@*RESULTS@#Low expression of GABA(A)alpha1 and GABA(B)1 were detected in solitary nucleus and ambiguous nucleus in the control brain tissue. In cases of tramadol-induced death, the expression of GABA(A)alpha1 and GABA(B)1 significantly increased.@*CONCLUSION@#The mechanism of tramadol intoxication death could be caused by respiratory depression induced by over-expression of GABA(A)alpha1 and GABA(B)1 in medulla oblongata solitary nucleus and ambiguous nucleus.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Transtornos Respiratórios
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Autopsia
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Coloração e Rotulagem
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Tramadol
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Bulbo
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Imuno-Histoquímica
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Estudos de Casos e Controles
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Causas de Morte
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Núcleo Solitário
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Receptores de GABA-B
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Ano de publicação:
2011
Tipo de documento:
Article