Expression of FAPalpha and TGF-beta1 in sudden deaths due to acute myocardial ischemia / 法医学杂志
Journal of Forensic Medicine
;
(6): 18-20, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-983705
ABSTRACT
OBJECTIVE@#To explore the expression of fibroblast activation protein alpha (FAPalpha) and transforming growth factor-beta1 (TGF-beta1) in myocardial cytoplasm for the cases of sudden death due to acute myocardial ischemia.@*METHODS@#The heart tissues of 47 cases were collected. All cases were divided into three groups control group, acute myocardial infarction group and recurrent myocardial infarction group. FAPalpha and TGF-beta1 expressions were explored in myocardial cytoplasm by immunohistochemistry technology. The staining results were collected by image analysis system and then the positive area ratio and average optical density were detected. The positive signal differences were compared among the groups.@*RESULTS@#Strong FAPalpha and TGF-beta1 expressions were detected in myocardial cytoplasm in both acute and recurrent myocardial infarction groups. The expression of FAPalpha was not detected in myocardial cytoplasm in control group and TGF-beta1 expression showed a weak positive result. FAPalpha and TGF-beta1 expressions showed the statistical difference (P < 0.05) in myocardial infarction (acute and recurrent) groups and control group.@*CONCLUSION@#FAPalpha and TGF-beta1 can be the diagnostic markers for determing acute myocardial infarction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Endopeptidases
/
Recidiva
/
Autopsia
/
Imuno-Histoquímica
/
Serina Endopeptidases
/
Doença Aguda
/
Estudos Retrospectivos
/
Morte Súbita Cardíaca
/
Isquemia Miocárdica
/
Gelatinases
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS