Magnetic resonance diffusion tensor imaging for diagnosis of pyramidal tract damage in rats / 法医学杂志
Journal of Forensic Medicine
;
(6): 256-268, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-983744
ABSTRACT
OBJECTIVE@#To explore the applicability of magnetic resonance diffusion tensor imaging (DTI) for diagnosis of pyramidal tract damage in rats.@*METHODS@#Marmarou's model was set up, followed by DTI scanning at 3, 12, 24 and 72 h post trauma to acquire the dispersion parameter of bilateral pyramidal tracts. Moreover, axonal varicosities per square millimeter and the percentage of positive area of axons demonstrated by beta-amyloid precursor protein (beta-APP) immunostaining were obtained, as well as the mean density and sum density of neurofilament (NF) 68 immunostaining.@*RESULTS@#Axial diffusivity (AD), fraction anisotropy (FA) and relative anisotropy (RA) in the pyramidal tract were significantly and continuously reduced and reached to the bottom at 72h post trauma (P < 0.05) in accord with the gradient of axonal damage verified by beta-APP and NF68 immunostaining. Furthermore, the changes of AD, FA and RA showed a significant negative correlation with the beta-APP immunohistochemical results.@*CONCLUSION@#DTI has important value for early diagnosis in pyramidal tract damage.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tratos Piramidais
/
Axônios
/
Fatores de Tempo
/
Índice de Gravidade de Doença
/
Processamento de Imagem Assistida por Computador
/
Encéfalo
/
Lesões Encefálicas
/
Proteínas de Neurofilamentos
/
Anisotropia
/
Precursor de Proteína beta-Amiloide
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo
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