Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina
Korean Circulation Journal
;
: 44-49, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-98377
ABSTRACT
BACKGROUND AND OBJECTIVES:
The recently discovered myokine irisin has a proposed role in adipose tissue metabolism. The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD). SUBJECTS ANDMETHODS:
Sixty-three patients who underwent coronary angiography (CA) diagnosed with stable CAD and twenty-six patients with normal coronary artery (NCA) were enrolled in the study. Stable CAD patients were divided into two groups as high synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score (≥23) and lower SYNTAX score (<23). Serum irisin level measurement was carried out using human irisin colorimetric enzyme-linked immunosorbent assay (ELISA) commercial kit (AG-45A-0046EK-KI01, Adipogen, San Diego, CA, USA) as recommended by the manufacturer's protocol.RESULTS:
The patients with stable CAD with a higher SYNTAX score (score ≥23) had significantly lower serum irisin levels (127.91±55.38 ng/mL), as compared the patients with a low SYNTAX score (score <23) (224.69±92.99 ng/mL) and control group (299.54±123.20 ng/mL). Irisin levels showed significant differences between all groups (p<0.001).CONCLUSION:
Serum irisin level is an independent predictor of coronary artery severity in patients with stable CAD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cirurgia Torácica
/
Doença da Artéria Coronariana
/
Ensaio de Imunoadsorção Enzimática
/
Tecido Adiposo
/
Angiografia Coronária
/
Vasos Coronários
/
Taxus
/
Aterosclerose
/
Angina Estável
/
Intervenção Coronária Percutânea
Tipo de estudo:
Guia de Prática Clínica
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2017
Tipo de documento:
Artigo
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