Genetic polymorphisms of four SNP loci in D5 gene of dopamine receptor in Northern Chinese Han population / 法医学杂志
Journal of Forensic Medicine
;
(6): 37-48, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-983791
ABSTRACT
OBJECTIVE@#To reveal the genetic polymorphisms of four SNP loci (rs77434921, rs2076907, rs6283, rs1800762) in D5 gene of dopamine receptor (DRD5) in Northern Chinese Han population.@*METHODS@#Four SNP loci of the DRD5 gene of 206 unrelated individuals in Northern Chinese Han population were separately amplified and sequenced by PCR technique and statistically analyzed by Haploview v4.1 software.@*RESULTS@#In Northern Chinese Han population, the genotype frequency distribution of rs77434921, rs2076907, rs6283 and rs1800762 loci in the DRD5 gene were all in accordance with Hardy-Weinberg equilibrium. DP value was 0.145, 0.532, 0.602 and 0.159, while PE value was 0.004, 0.079, 0.196 and 0.007. A linkage disequilibrium among these four SNP loci was also demonstrated, which might infer five haplotypes.@*CONCLUSION@#rs2076907 and rs6283 loci of DRD5 gene in the Northern Chinese Han population have high genetic polymorphisms, which can be useful for forensic identification of individuals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Haplótipos
/
Marcadores Genéticos
/
Desequilíbrio de Ligação
/
China
/
Reação em Cadeia da Polimerase
/
Primers do DNA
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Receptores de Dopamina D5
/
Genética Forense
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS