Your browser doesn't support javascript.
loading
Method development and validation for determining 1,3-butadiene in human blood by gas chromatography-mass spectrometry and head-space gas chromatography / 法医学杂志
Journal of Forensic Medicine ; (6): 110-115, 2013.
Artigo em Inglês | WPRIM | ID: wpr-983802
ABSTRACT
To develop a simple, validated method for identifying and quantifying 1,3-butadiene (BD) in human blood by gas chromatography-mass spectrometry (GC-MS) and head-space gas chromatography (HS-GC). BD was identified by GC-MS and HS-GC, and quantified by HS-GC. The method showed that BD had a good linearity from 50 to 500 microg/mL (r > 0.99). The limits of detection and quantification were 10 microg/mL and 50 microg/mL, respectively. Both the intra-day precision and inter-day precision were < 6.08%, and the accuracy was 96.98%-103.81%. The method was applied to an actual case, and the concentration of BD in the case was 242 microg/mL in human blood. This simple method is found to be useful for the routine forensic analysis of acute exposure to BD.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Solventes / Temperatura / Butadienos / Reprodutibilidade dos Testes / Sensibilidade e Especificidade / Toxicologia Forense / Intoxicação por Gás / Cromatografia Gasosa-Espectrometria de Massas Limite: Adulto / Humanos / Masculino Idioma: Inglês Revista: Journal of Forensic Medicine Ano de publicação: 2013 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Solventes / Temperatura / Butadienos / Reprodutibilidade dos Testes / Sensibilidade e Especificidade / Toxicologia Forense / Intoxicação por Gás / Cromatografia Gasosa-Espectrometria de Massas Limite: Adulto / Humanos / Masculino Idioma: Inglês Revista: Journal of Forensic Medicine Ano de publicação: 2013 Tipo de documento: Artigo