Expression of GAP-43 in midbrain ventral tegmental area of morphine withdrawal rats / 法医学杂志
Journal of Forensic Medicine
;
(6): 330-336, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-983844
ABSTRACT
OBJECTIVE@#To observe the protein expression of growth associated protein-43 (GAP-43) in midbrain ventral tegmental area in morphine withdrawal rats at different time, and to evaluate the effect of GAP-43 on morphine withdrawal memory.@*METHODS@#Rat models of morphine dependent 1 week, 2 weeks and 4 weeks were established by morphine hydrochloride intraperitoneal injection with increasing doses to establish natural withdrawal. The protein expression of GAP-43 in midbrain ventral tegmental area was observed by immunohistochemical staining and the results were analyzed by Image-Pro Plus 5.1 image analysis system.@*RESULTS@#With prolongation of dependent time, the expression of GAP-43 was decreased then increased in midbrain ventral tegmental area.@*CONCLUSION@#GAP-43 could play a role in morphine withdrawal memory in midbrain ventral tegmental area.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndrome de Abstinência a Substâncias
/
Fatores de Tempo
/
Comportamento Animal
/
Mesencéfalo
/
Imuno-Histoquímica
/
Ratos Sprague-Dawley
/
Área Tegmentar Ventral
/
Proteína GAP-43
/
Modelos Animais de Doenças
/
Morfina
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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