Gene detection of GPD1-L and the association with sudden unexplained death syndrome in young adults / 法医学杂志
Journal of Forensic Medicine
;
(6): 348-352, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-983849
ABSTRACT
OBJECTIVE@#To analyze the variations of glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) and address the association with sudden manhood death syndrome (SMDS).@*METHODS@#The genomic DNA was extracted from blood samples of the SMDS group and the normal control group. The exons, exon-intron boundaries and 3'-UTRs of coding region of GPD1-L were PCR amplified and DNA sequenced directly to confirm the types of variations. The genotype frequency and allele frequency were analyzed statistically.@*RESULTS@#There were two variants in the SMDS group, c.465C>T and c.*18G>T, the latter existed certain degree difference of genotype distribution and allele frequency between the SMDS group and the control group, but there was no statistically significant (P > 0.05).@*CONCLUSION@#The relation between gene mutation of GPD1-L and the occurrence of Chinese SMDS deserves a further research.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Análise Mutacional de DNA
/
Sequência de Bases
/
Estudos de Casos e Controles
/
Reação em Cadeia da Polimerase
/
Éxons
/
Primers do DNA
/
Polimorfismo de Nucleotídeo Único
/
Morte Súbita
/
Povo Asiático
/
Frequência do Gene
Limite:
Adolescente
/
Adulto
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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