Time-related expression of IL-6, IL-8 and TNF-alpha following explosive injury to rabbit's chest / 法医学杂志

ABSTRACT

OBJECTIVE@#To explore the relationship between the expression changes of cytokines, interleukin-6 (IL-6), interleukin-8(IL-8), and tumor necrosis factor-alpha (TNF-alpha), and the wound time following explosive injury to rabbit's chest.@*METHODS@#The rabbit's model of explosive injury was established. The expression levels of IL-6, IL-8 and TNF-alpha in the plasma were detected by ELISA method at different wound time (0.5-12h).@*RESULTS@#The level of IL-6 increased at 3h after wounding and reached peak at 6 h. The level of IL-8 increased at 1 h and reached peak at 6 h. The level of TNF-alpha increased at 0.5 h and reached peak at 3 h.@*CONCLUSION@#IL-6, IL-8 and TNF-alpha have a time-related expression after explosive injury.