Expression of CaMK II delta in cerebral cortex following traumatic brain injury / 法医学杂志
Journal of Forensic Medicine
;
(6): 169-177, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-983899
ABSTRACT
OBJECTIVE@#To observe the time-course expression of calcium-calmodulin dependent protein kinase II delta (CaMK II delta) in cerebral cortex after traumatic brain injury (TBI).@*METHODS@#The TBI rat model was established. The expression of CaMK II delta in cerebral cortex around injured area was tested by Western blotting and immunohistochemical staining.@*RESULTS@#Western blotting revealed expression of CaMK II delta in normal rat brain cortex. It gradually increased after TBI, peaked after 3 days, and then returned to normal level. The result of immunohistochemical staining was consistent with that of Western blotting.@*CONCLUSION@#The expression of CaMK II delta around injured area after TBI increased initially and then decreased. It could be used as a new indicator for wound age determination following TBI.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Tempo
/
Lesões Encefálicas
/
Imuno-Histoquímica
/
Córtex Cerebral
/
Western Blotting
/
Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina
/
Medicina Legal
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2014
Tipo de documento:
Artigo
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