Research Progress on Forensic Toxicology of Z-drugs / 法医学杂志
Journal of Forensic Medicine
;
(6): 293-297, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-984003
ABSTRACT
The Z-drugs (zolpidem, zopiclone, and zaleplon), as the innovative hypnotics, have an improvement over the traditional benzodiazepines in the management of insomnia. Z-drugs have significant hypnotic effects by reducing sleep latency and improving sleep quality, though duration of sleep may not be significantly increased. As benzodiazepines, Z-drugs exert their effects through increasing the transmission of γ-aminobutyric acid. Z-drugs overdose are less likely to be fatal, more likely would result in poisoning. Z-drugs can be detected in blood, urine, saliva, and other postmortem specimens through liquid chromatography-mass spectrometry techniques. Zolpidem and zaleplon exhibit significant postmortem redistribution. Z-drugs have improved pharmacokinetic profiles, but incidence of neuropsychiatric sequelae, poisoning, and death may prove to be similar to the other hypnotics. This review focuses on the pharmacology and toxicology of Z-drugs with respect to their adverse effect profile and toxicity and toxicology data in the field of forensic medicine.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Piperazinas
/
Piridinas
/
Pirimidinas
/
Toxicologia Forense
/
Compostos Azabicíclicos
/
Overdose de Drogas
/
Medicina Legal
/
Zolpidem
/
Hipnóticos e Sedativos
/
Distúrbios do Início e da Manutenção do Sono
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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