Progress on Hypoxic-ischemic Brain Damage Associated with CCR2 and CCL2 / 法医学杂志
Journal of Forensic Medicine
;
(6): 54-57, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-984043
ABSTRACT
Hypoxic-ischemic brain damage (HIBD) is referred to a common type of cerebral damage, which is caused by injury, leading to shallow bleeding in the cortex with intact cerebral pia mater. In recent years, studies show that a various kinds of immune cells and immune cellular factors are involved in the occurrence of HIBD. CC chemokine receptor 2 (CCR2) is a representative of CC chemokine receptor, and is widely distributed in cerebral neuron, astrocyte, and microglial cells, and is the main chemo-tactic factor receptor in brain tissue. CC chemokine ligand 2 (CCL2) is a kind of basophilic protein and the ligand of CCR2, and plays an important role in inflammation. In order to provide evidence for correlational studies in HIBD, this review will introduce the biological characteristics of CCR2 and CCL2, and illustrate the relationship between the immunoreactivity and HIBD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Lesões Encefálicas
/
RNA Mensageiro
/
Córtex Cerebral
/
Ratos Sprague-Dawley
/
Quimiocina CCL2
/
Proteínas Inflamatórias de Macrófagos
/
Quimiocinas CC
/
Hipóxia-Isquemia Encefálica
/
Receptores CCR2
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2016
Tipo de documento:
Artigo
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