RUNX1::RUNX1T1 Fusion in Pediatric Acute Myeloid Leukemia: A description of two cases
Philippine Journal of Pathology
;
(2): 42-48, 2023.
Artigo
em Inglês
| WPRIM
| ID: wpr-984547
ABSTRACT
@#RUNX1RUNX1T1 is a core-binding factor driving fusion gene which arises from t(8;21)(q22;q22). It is one of the most common chromosomal rearrangements in both pediatric and adult Acute Myeloid Leukemia (AML) with a reported incidence o 15% in children and young adults. There are few case reports documenting RUNX1RUNX1T1 translocation in pediatric AML. Although this is generally associated with a favorable prognosis, we report two (2) cases of de novo pediatric AML in the Philippines harboring a RUNX1RUNX1T1 translocation, one eventually relapsed while the other attained remission but succumbed to sepsis.
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sequenciamento de Nucleotídeos em Larga Escala
Idioma:
Inglês
Revista:
Philippine Journal of Pathology
Ano de publicação:
2023
Tipo de documento:
Artigo
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