Pathogenesis and Drug Therapy in Traditional Chinese and Western Medicine of Postpartum Lochia：A Review / 中国实验方剂学杂志

ABSTRACT

Postpartum lochia （PL） is an abnormal postpartum retrogression disease characterized by persistent bloody lochia lasting for more than 10 days. The pathogenesis of traditional Chinese and western medicine is complex，and the mechanism of drug action is not yet clear. The author summarized the pathogenesis and drug action mechanism of postpartum lochia from the perspectives of traditional Chinese and Western medicine by reviewing relevant domestic and foreign research in recent years. It was found that the basic pathogenesis of this disease is the imbalance of Chong Ren Qi and blood，multiple deficiency and multiple stasis. Commonly used drugs are divided into single traditional Chinese medicine and traditional Chinese medicine compound formulas and their preparations. By regulating the transcription and expression of related factors through multiple targets and pathways，it promotes uterine contraction，regulates collagen metabolism Regulating the expression of hormones and their receptors，promoting vascular regeneration，regulating cell apoptosis，proliferation and differentiation，downregulating inflammatory response，maintaining blood coagulation balance，and affecting energy metabolism in the body can promote postpartum recovery. Western medicine is often associated with mechanisms such as incomplete uterine involution，residual tissue，and intrauterine infections. The treatment mainly involves the combination of uterine contractions and antibiotics，with a single mode of action and mechanism. Therefore，traditional Chinese medicine has obvious and concrete advantages in treatment. This article aims to review the etiology and pathogenesis of postpartum lochia in traditional Chinese and western medicine，as well as drug treatment. It aims to construct the relationship between its pathogenesis and mechanism of action，providing reference for the clinical diagnosis and treatment of this disease and drug research and development.