The Role of CBS in Injury Time Estimation after Brain Contusion / 法医学杂志
Journal of Forensic Medicine
;
(6): 221-224, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-984880
ABSTRACT
OBJECTIVES@#To observe the changes of cystathionine β-synthase (CBS) expression in the cerebral cortex after brain contusion at different times.@*METHODS@#An experimental model of traumatic brain injury (TBI) in mice was established by an improved weight-drop device. Then Western blotting and immunohistochemical examination were used to detect the CBS expression in cerebral cortex around injury at different time points (1 h, 6 h, 12 h, 1 d, 2 d, 3 d, 7 d).@*RESULTS@#The results of Western blotting revealed that the expression level of CBS was down-regulated and reached its lowest level at the 3rd days after injury, and then restored to normal level after 7 days. The results of immunohistochemistry showed that CBS was present in the normal brain cortex. CBS expression gradually decreased at the 3rd days after injury, and then restored to normal level after 7 days.@*CONCLUSIONS@#CBS has the potential to be a reference index for time estimation after brain contusion in forensic practice.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Tempo
/
Encéfalo
/
Lesões Encefálicas
/
Imuno-Histoquímica
/
Regulação para Baixo
/
Córtex Cerebral
/
Western Blotting
/
Cistationina beta-Sintase
/
Contusão Encefálica
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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