Polymorphism and Forensic Application Value of 71 Y-SNP Loci in Han Population of Northwest China / 法医学杂志
Journal of Forensic Medicine
;
(6): 23-29, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-984975
ABSTRACT
OBJECTIVES@#To analyze the polymorphism of 71 SNP loci on Y chromosome in Han population of Northwest China, to assess its forensic application value, and to screen out Y-SNP loci for forensic examination of Han population in East, South, and Northwest China based on the integration of previous research results.@*METHODS@#Multiplex polymerase chain reaction (PCR) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) were performed on 71 Y-SNP loci of 202 unrelated Han male individuals in Northwest China. Gene diversity (GD) and haplotype diversity (HD) values were calculated, and then Y-SNP loci of Han population in East, South, and Northwest China were screened with the combination of data from previous research.@*RESULTS@#Among the detected 71 loci, 67 loci were polymorphic in the Northwest Han male population, with GD values 0.010 0-0.502 2. There were 22 and 25 loci with a moderate (0.2≤GD<0.3) and high (GD≥0.3) amount of genetic information, respectively. There were 26 loci for the Han communities in Northwest, South, and East China.@*CONCLUSIONS@#Y-SNP loci are potential in paternity testing and individual identification, as well as the judgement of population distribution and migration.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Haplótipos
/
China
/
Cromossomos Humanos Y
/
Povo Asiático
/
Frequência do Gene
/
Genética Populacional
Limite:
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2019
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS