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Research Progress on Metabolite Identification of Synthetic Cannabinoid New Psychoactive Substances / 法医学杂志
Journal of Forensic Medicine ; (6): 459-459, 2021.
Artigo em Chinês | WPRIM | ID: wpr-985234
ABSTRACT
Synthetic cannabinoids are currently a class of new psychoactive substances with the largest variety and most abused. Metabolite identification research can provide basic data for monitoring synthetic cannabinoids abuse, which is the current research hotspot. The main trend of structural modification of synthetic cannabinoid is to replace the fluorine atom on pentyl indole or indazole cyclopentyl with hydrogen atom, which greatly improves the biological activity of the compound. The main metabolic reactions include hydroxylation, fluoropentyl oxidative, ester hydrolyze, amide hydrolysis. Liquid chromatography-high resolution mass spectrometry has become the preferred choice for the structural identification of metabolites. This review mainly summarizes research on metabolism software prediction and human hepatocyte model, human liver microsomes model, rat in vivo model, zebrafish model and fungus C. elegans model in metabolite identification based on the structure and classification of synthetic cannabinoids.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Peixe-Zebra / Canabinoides / Microssomos Hepáticos / Cromatografia Líquida / Caenorhabditis elegans Limite: Animais Idioma: Chinês Revista: Journal of Forensic Medicine Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Peixe-Zebra / Canabinoides / Microssomos Hepáticos / Cromatografia Líquida / Caenorhabditis elegans Limite: Animais Idioma: Chinês Revista: Journal of Forensic Medicine Ano de publicação: 2021 Tipo de documento: Artigo