The Relationship between Expression of Hypoxia Inducible Factor-1alpha or Vascular Endothelial Growth Factor and Histopathological Characteristics in Human Renal Cell Carcinoma / 대한비뇨기과학회지
Korean Journal of Urology
;
: 303-308, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-9853
ABSTRACT
PURPOSE:
HIF-1alpha (Hypoxia inducible factor-1alpha) and VEGF (vascular endothelial growth factor) have been reported to be involved in tumor growth and metastasis, but only a little data on the roles of HIF-1alpha and VEGF in renal cell carcinomas are available, and few studies have yet evaluated their prognostic values. The aim of the present study was to assess the HIF-1alpha and VEGF expression and evaluate the relationships between HIF-1alpha/VEGF and the histopathological characteristics in renal cell carcinomas. MATERIALS ANDMETHODS:
HIF-1alpha and VEGF immunohistochemical stainings were performed on formalin-fixed, paraffin-embedded archival tissues from 22 renal cell carcinoma tissues and 13 normal kidney tissues, used as a control group. The interpretation of the immunohistochemical stainings were semi-quantitatively performed by one pathologist.RESULTS:
The expressions of HIF-1alpha and VEGF were significantly higher in the patient than the control group. The HIF-1alpha and VEGF expressions were correlated to each other, and inclined to be positively correlated with the pathological stage and grade of the renal cell carcinoma.CONCLUSIONS:
The HIF-1alpha and VEGF expressions might be independent predictors of the outcome, as well as the stage and grade of renal cell carcinomas. This study suggests that HIF-1alpha and VEGF may be potential prognostic factors in renal cell carcinomas.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Carcinoma de Células Renais
/
Fator A de Crescimento do Endotélio Vascular
/
Indutores da Angiogênese
/
Rim
/
Hipóxia
/
Metástase Neoplásica
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
2004
Tipo de documento:
Artigo
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