Bacterial growth in placental swab cultures done among women who received Ampicillin Prophylaxis for term prelabor rupture of membranes: Matched cohort study

ABSTRACT

Background@#Term prelabor rupture of membranes (PROM) increases the risk of maternal and neonatal infections. @*Objective@#To compare rates of positive bacterial growth in placental swab cultures done among women who received ampicillin prophylaxis at different timings after term PROM. @*Design@#Matched cohort study. @*Setting@#Department of Obstetrics and Gynecology at Southern Philippines Medical Center in Davao City, Philippines. @*Participants@#120 pregnant women aged ≥18 years old, at ≥37 weeks age of gestation, with PROM 40 women received ampicillin within 6 hours (6H group), 40 within >6 to 12 hours (12H group), and 40 within >12 to 18 hours (18H group) of onset of PROM. @*Main outcome measures@#Rates of positive bacterial growth in postpartum placental swab cultures; most common bacterial isolates; and signs of intraamniotic infection (IAI).