Advances in Mechanotransduction Pathway of Macrophage / 医用生物力学
Journal of Medical Biomechanics
;
(6): E408-E414, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-987966
ABSTRACT
Mechanical stimulation in micro-environment ( such as matrix stiffness, surface topography, cyclical stretch) can be perceived by macrophages through receptors on cell membrane, transmitted to the nucleus along the adhesion protein molecular chain and cytoskeleton, and also converted into biochemical signal to stimulate gene transcription. Mechanical stimulation drives various biological functions in macrophages, such as adhesion, proliferation, migration, and polarization, thereby playing a corresponding role in disease progression and tissue regeneration. This study demonstrates the role of micro-environment mechanics in macrophages polarization and function, and elucidates the related mechanism of mechanotransduction pathway in macrophages, so as to provide molecular biomechanics insights into the development of macrophage-targeting immunomodulatorybiomaterials.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Medical Biomechanics
Ano de publicação:
2023
Tipo de documento:
Artigo
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