Progress in endogenous neural stem cells for neonatal brain injury / 国际儿科学杂志

ABSTRACT

Neonatal brain injury refers to the pathological damage of brain tissue caused by various factors in the perinatal period.The most common disorders are hypoxic-ischemic encephalopathy, periventricular-intraventricular hemorrhage, and periventricular leukomalacia.After a severe brain injury, the repair and reconstruction of the central nervous system (CNS) is crucial in restoring CNS architecture and function.The studies have shown that neural stem cells (NSC) have the potential for multidirectional differentiation and the ability to maintain self-renewal.Endogenous neural stem cells (eNSC) can proliferate, migrate to the lesion sites and finally differentiate into astrocytes, oligodendrocytes, and neurons, to provide new options for the treatment of neural regeneration.This paper aims to review the recent progress of eNSC in treating neonatal brain injury.