Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
Genomics & Informatics
;
: 59-63, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-98932
ABSTRACT
Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40~60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12, NFE2L3, MC4R and FTO) having p<1x10(-5). However, in the replication study, only melanocortin 4 receptor gene (MC4R) (rs9946888, p=4.58x10(-7)) was replicated with marginal significance (p<0.05) in the second cohort (n=5,102, age 40~60 years). This study indicates that each locus associated with BMI has very weak genetic effect.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Cardiovasculares
/
Índice de Massa Corporal
/
Estudos de Coortes
/
Receptor Tipo 4 de Melanocortina
/
Povo Asiático
/
Estudo de Associação Genômica Ampla
/
Loci Gênicos
/
Obesidade
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2011
Tipo de documento:
Artigo
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