The Clinical Features and the Clinical Outcome of Duodenal Brunner's Gland Adenoma

ABSTRACT

PURPOSE: The aim of this study was to characterize the clinical presentation and outcome of a series of patients with Brunner's gland adenoma. METHODS: Between 1996 and 2007, 15 patients who underwent surgical resection and 9 patients who underwent endoscopic polypectomy for pathologically confirmed Brunner's gland adenoma were identified. We reviewed the clinico-pathological features of these patients. RESULTS: The mean age of the total patients was 56 years and the male to female ratio was 1.4 to 1. There were no significant differences in age, gender and the polyp size between the surgical resection group and the endoscopic polypectomy group. Among the 15 patients of the surgery group, all 15 patients (100%) were symptomatic (p=0.031). The hospital stay in the endoscopic polypectomy group was significantly shorter than that in the surgery group (p=0.001). CONCLUSION: Brunner's gland adenoma is a rare duodenal tumor that occurs in middle age people and the patients with this tumor present with either gastrointestinal hemorrhage, obstructive symptoms or other incidental findings. Surgical or endoscopic excision for treating this tumor is uncomplicated, and the long-term outcome is favorable.