Effects of Long-term Intermittent Oxygen Administration on the Cognitive Function in Rats / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 687-693, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-98992
ABSTRACT
BACKGROUND:
Several studies have demonstrated that the transient administration of oxygen improves cognitive performance. However, the effect of long-term oxygen administration remains unknown. This study investigated the impact of long-term oxygen administration on cognitive enhancement.METHODS:
Six week old Sprague-Dawley rats (n = 46) were randomly allocated to one of three groups the control (Control; n = 15), 30 min/day oxygen administration (Oxy30min; n = 16) and 60 min/day oxygen administration groups (Oxy60min; n = 15). The rats in all three groups were administered air or oxygen for 10 weeks. The Morris water maze test was employed to assess the latency (L & Lt), dwelling time (DT) and the total fraction above the mean dwelling time (FmDT) for cognitive performance.RESULTS:
Compared to the control group, the Oxy30min and Oxy60min groups showed no differences in their L and Lt. There was a dose-response trend due to oxygen administration. Compared to the control group, the Oxy60min group had a significantly improved DT (P< 0.05). The FmDT also significantly increased in both of the oxygen administration groups, which also showed a dose-response trend (P<0.05).CONCLUSIONS:
The present results suggest that long-term (10 weeks) oxygen administration can dose-dependently enhance cognitive performance.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Ratos Sprague-Dawley
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2007
Tipo de documento:
Artigo
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