Classification and clinical roles of immune related-biomarkers in sepsis / 中国小儿急救医学
Chinese Pediatric Emergency Medicine
;
(12): 941-945, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-990453
ABSTRACT
Biomarkers of sepsis play critical roles in diagnosis, early recognition of organ dysfunction, risk stratification, prognostication, and therapeutic strategy.The dysregulated inflammatory response is reflected drastic changes in pathogen-associated molecular patterns and damage-associated molecular patterns, presented the changes of gene expression and epigenetic modification, metabolic reprogramming and immune dysfunction of immune cells.Sepsis is classified into hyperinflammatory phenotype and immunosuppression phenotype.Biomarker exploration is also conductive to understand the heterogeneity of sepsis and developing the individualized treatment strategies.This issue focused on novel immune-associated biomarkers for prognostic prediction that could be useful to optimize patient management.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pediatric Emergency Medicine
Ano de publicação:
2022
Tipo de documento:
Artigo
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